方法对比
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| 时间序列蛋白质组学分析× | 时间序列代谢组学分析× | |
|---|---|---|
| 领域 | 生物信息学 | 生物信息学 |
| 方法族 | Process / pipeline | Process / pipeline |
| 起源年份≠ | 2000s (quantitative framework: Gygi et al. 1999; time-series designs: 2004–2010) | 2000s–2010s |
| 提出者≠ | Multiple groups; Gygi et al. (1999) established quantitative proteomics; time-series designs emerged in the 2000s with LC-MS/MS workflows | Developed from general metabolomics workflows; longitudinal extensions pioneered by A. K. Smilde, R. Bino, and colleagues |
| 类型 | Quantitative longitudinal omics pipeline | Quantitative longitudinal omics pipeline |
| 开创性文献≠ | Lemeer, S., & Heck, A. J. R. (2012). The phosphoproteomics data explosion. Current Opinion in Chemical Biology, 16(1–2), 1–8. link ↗ | Smilde, A. K., van der Werf, M. J., Bijlsma, S., van der Werff-van der Vat, B. J. C., & Jellema, R. H. (2005). Fusion of mass spectrometry-based metabolomics data. Analytical Chemistry, 77(20), 6729–6736. link ↗ |
| 别名 | longitudinal proteomics, temporal proteomics, dynamic proteomics, time-course proteomics | longitudinal metabolomics, dynamic metabolomics, temporal metabolome profiling, kinetic metabolomics |
| 相关 | 6 | 6 |
| 摘要≠ | Time-series proteomics analysis quantifies protein abundance across two or more ordered time points to reveal how the proteome changes dynamically in response to stimuli, developmental stages, or disease progression. By combining mass spectrometry-based protein quantification with statistical models designed for temporal data, the method identifies proteins with significant expression trends, oscillatory patterns, or delayed responses that cannot be detected in single time-point studies. | Time-series metabolomics analysis profiles small-molecule metabolites from biological samples collected at multiple, ordered time points, enabling researchers to capture the dynamic flux of metabolic pathways in response to stimuli, disease progression, drug treatment, or developmental change. By integrating longitudinal statistical models with standard metabolomics preprocessing, the approach goes beyond a static metabolic snapshot to reveal how, when, and in what sequence metabolic responses unfold. |
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