方法对比

	稳健型 Box-Behnken 设计	响应面方法 (RSM)
领域	实验设计	实验设计
方法族	Process / pipeline	Hypothesis test
起源年份	1960 (BBD); robust integration practice emerged 1990s–2000s	1951
提出者	Box & Behnken (BBD foundation); robust integration drawing on Taguchi (1986) and Myers et al.	George E. P. Box & K. B. Wilson
类型	Experimental design with robustness optimization	Second-order polynomial response surface model
开创性文献	Box, G. E. P., & Behnken, D. W. (1960). Some new three level designs for the study of quantitative variables. Technometrics, 2(4), 455–475.	Box, G. E. P. & Wilson, K. B. (1951). On the experimental attainment of optimum conditions. Journal of the Royal Statistical Society, Series B, 13(1), 1–45.
别名	Robust BBD, BBD robust parameter design, robust response surface BBD, noise-robust Box-Behnken	RSM, Central Composite Design, Box-Behnken Design, CCD
相关	4	7
摘要	Robust Box-Behnken design combines the efficiency of the Box-Behnken design (BBD) — a three-level response surface design requiring no corner runs — with robust parameter design principles to identify factor settings that optimize the mean response while simultaneously minimizing sensitivity to uncontrollable noise factors. It is widely applied in manufacturing, chemical engineering, and product development when both performance and consistency under real-world variation matter.	Response Surface Methodology is a collection of statistical and mathematical techniques for building an empirical second-order polynomial model that relates a continuous response variable to two or more controllable input factors, and then locating the factor settings that optimize that response. The approach was introduced by George E. P. Box and K. B. Wilson in their landmark 1951 paper and has since become a cornerstone of process optimization across engineering, chemistry, food science, and pharmaceutics.