方法对比

	基于风险的中心复合设计	响应面方法 (RSM)
领域	实验设计	实验设计
方法族	Process / pipeline	Hypothesis test
起源年份	1951 (CCD); risk-based integration emerged in applied engineering literature from the 1990s onward	1951
提出者	Foundational CCD: George E. P. Box & K. B. Wilson (1951); risk integration adapted from engineering risk analysis traditions	George E. P. Box & K. B. Wilson
类型	Experimental design with integrated risk assessment	Second-order polynomial response surface model
开创性文献	Box, G. E. P., & Wilson, K. B. (1951). On the experimental attainment of optimum conditions. Journal of the Royal Statistical Society: Series B, 13(1), 1–45.	Box, G. E. P. & Wilson, K. B. (1951). On the experimental attainment of optimum conditions. Journal of the Royal Statistical Society, Series B, 13(1), 1–45.
别名	Risk-informed CCD, CCD with risk assessment, Uncertainty-aware central composite design, Risk-integrated RSM	RSM, Central Composite Design, Box-Behnken Design, CCD
相关	5	7
摘要	Risk-based Central Composite Design (Risk-based CCD) integrates formal risk identification and uncertainty quantification into the classical CCD framework. By coupling the rotatable second-order experimental structure of CCD with probabilistic risk metrics, engineers and scientists can simultaneously optimize process responses and characterize the risk of unacceptable outcomes — making it particularly valuable in regulated industries such as pharmaceuticals, chemical engineering, and advanced manufacturing.	Response Surface Methodology is a collection of statistical and mathematical techniques for building an empirical second-order polynomial model that relates a continuous response variable to two or more controllable input factors, and then locating the factor settings that optimize that response. The approach was introduced by George E. P. Box and K. B. Wilson in their landmark 1951 paper and has since become a cornerstone of process optimization across engineering, chemistry, food science, and pharmaceutics.