方法对比

	基于风险的中心复合设计	Box-Behnken Design
领域	实验设计	实验设计
方法族	Process / pipeline	Process / pipeline
起源年份	1951 (CCD); risk-based integration emerged in applied engineering literature from the 1990s onward	1960
提出者	Foundational CCD: George E. P. Box & K. B. Wilson (1951); risk integration adapted from engineering risk analysis traditions	George E. P. Box and Donald W. Behnken
类型	Experimental design with integrated risk assessment	Response surface design (incomplete three-level factorial)
开创性文献	Box, G. E. P., & Wilson, K. B. (1951). On the experimental attainment of optimum conditions. Journal of the Royal Statistical Society: Series B, 13(1), 1–45.	Box, G. E. P., & Behnken, D. W. (1960). Some new three level designs for the study of quantitative variables. Technometrics, 2(4), 455–475.
别名	Risk-informed CCD, CCD with risk assessment, Uncertainty-aware central composite design, Risk-integrated RSM	BBD, Box-Behnken, Box-Behnken RSM design, three-level incomplete factorial design
相关	5	3
摘要	Risk-based Central Composite Design (Risk-based CCD) integrates formal risk identification and uncertainty quantification into the classical CCD framework. By coupling the rotatable second-order experimental structure of CCD with probabilistic risk metrics, engineers and scientists can simultaneously optimize process responses and characterize the risk of unacceptable outcomes — making it particularly valuable in regulated industries such as pharmaceuticals, chemical engineering, and advanced manufacturing.	The Box-Behnken design (BBD) is an efficient response surface methodology design that fits a full second-order polynomial model using three levels of each factor. Introduced by Box and Behnken in 1960, it places experimental points at the midpoints of the edges of a hypercube and at the center, avoiding the corner points where all factors are simultaneously at their extreme levels. This structure makes BBD particularly attractive when extreme-level combinations are physically impossible, costly, or unsafe to test.