方法对比
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| 风险调整的Kaplan-Meier分析× | Cox比例风险模型× | |
|---|---|---|
| 领域 | 流行病学 | 流行病学 |
| 方法族 | Process / pipeline | Process / pipeline |
| 起源年份≠ | 2001–2004 (formal statistical framework for weighted KM curves) | 1972 |
| 提出者≠ | Conceptual basis: Kaplan & Meier (1958); risk-adjustment via IPTW formalised by Hernán, Brumback & Robins (2001), with practical implementation by Cole & Hernán (2004) | Sir David Roxbee Cox |
| 类型≠ | Adjusted non-parametric survival method | Semi-parametric regression model |
| 开创性文献≠ | Cole, S. R., & Hernan, M. A. (2004). Adjusted survival curves with inverse probability weights. Computer Methods and Programs in Biomedicine, 75(1), 45–49. DOI ↗ | Cox, D. R. (1972). Regression models and life-tables. Journal of the Royal Statistical Society: Series B (Methodological), 34(2), 187–202. DOI ↗ |
| 别名 | weighted Kaplan-Meier, IPTW-adjusted Kaplan-Meier, propensity-score-weighted survival curves, adjusted survival curves | Cox regression, Cox PH model, proportional hazards model, CPH |
| 相关 | 5 | 5 |
| 摘要≠ | Risk-adjusted Kaplan-Meier analysis combines the non-parametric Kaplan-Meier estimator with inverse probability of treatment weighting (IPTW) or similar risk-adjustment procedures to produce survival curves that are comparable across groups as if the groups had identical distributions of baseline confounders. It is the observational-study analogue of plotting survival curves from a randomised trial. | The Cox proportional hazards model is a semi-parametric regression method that estimates the effect of one or more covariates on the hazard — the instantaneous rate of an event such as death, relapse, or failure — while making no assumption about the shape of the baseline hazard function. Introduced by David Cox in 1972, it is the dominant tool for multivariable survival analysis in clinical and epidemiological research. |
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