方法对比
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| 风险调整剂量-反应分析× | Cox比例风险模型× | |
|---|---|---|
| 领域 | 流行病学 | 流行病学 |
| 方法族 | Process / pipeline | Process / pipeline |
| 起源年份≠ | 1980s-1990s (formalized in modern epidemiology) | 1972 |
| 提出者≠ | Sander Greenland; Kenneth Rothman (foundational epidemiological methods) | Sir David Roxbee Cox |
| 类型≠ | Epidemiological modeling technique | Semi-parametric regression model |
| 开创性文献≠ | Greenland, S. (1995). Dose-response and trend analysis in epidemiology: alternatives to categorical analysis. Epidemiology, 6(4), 356-365. DOI ↗ | Cox, D. R. (1972). Regression models and life-tables. Journal of the Royal Statistical Society: Series B (Methodological), 34(2), 187–202. DOI ↗ |
| 别名 | confounder-adjusted dose-response, covariate-adjusted dose-response modeling, risk-stratified dose-response analysis, adjusted exposure-response analysis | Cox regression, Cox PH model, proportional hazards model, CPH |
| 相关≠ | 4 | 5 |
| 摘要≠ | Risk-adjusted dose-response analysis quantifies the relationship between increasing levels of an exposure (dose) and the probability or magnitude of an outcome (response), while simultaneously controlling for baseline risk factors that could confound or modify this relationship. The method is widely applied in clinical epidemiology, pharmacoepidemiology, and environmental health research to isolate the causal contribution of exposure intensity from background risk heterogeneity among participants. | The Cox proportional hazards model is a semi-parametric regression method that estimates the effect of one or more covariates on the hazard — the instantaneous rate of an event such as death, relapse, or failure — while making no assumption about the shape of the baseline hazard function. Introduced by David Cox in 1972, it is the dominant tool for multivariable survival analysis in clinical and epidemiological research. |
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