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风险调整病例对照研究×病例对照研究×
领域流行病学流行病学
方法族Process / pipelineProcess / pipeline
起源年份1950s–1980s (case-control design from 1950; risk-adjustment conventions established by 1980s)1950s (formal methodology); precursors in the 1920s
提出者Doll & Hill (foundational case-control); risk adjustment via multivariate logistic regression systematised by Schlesselman (1982) and Breslow & Day (1980)Janet Lane-Claypon (early precursors, 1926); formalized by Brian MacMahon and Jerome Cornfield in the 1950s–1960s
类型Observational analytic study designObservational analytic study design
开创性文献Schlesselman, J. J. (1982). Case-Control Studies: Design, Conduct, Analysis. Oxford University Press. ISBN: 978-0195029697Schlesselman, J.J. (1982). Case-Control Studies: Design, Conduct, Analysis. Oxford University Press. ISBN: 978-0195027860
别名adjusted case-control study, covariate-adjusted case-control, risk-stratified case-control study, matched and adjusted case-control studycase-referent study, case-control design, retrospective case-control, case-control analysis
相关56
摘要A risk-adjusted case-control study is an observational design that identifies individuals with a disease outcome (cases) and comparable individuals without it (controls), then uses statistical adjustment — most commonly multivariable logistic regression — to estimate the association between an exposure and the outcome while controlling for confounding risk factors. The adjustment step is what distinguishes this variant from a simple case-control study, producing odds ratios that better reflect the independent contribution of the exposure of interest.A case-control study is a retrospective observational design in which individuals who have developed a disease or outcome of interest (cases) are compared with individuals who have not (controls) to determine whether prior exposure to a putative risk factor differs between the two groups. The primary measure of association is the odds ratio, which approximates the relative risk when the outcome is rare. Case-control studies are especially efficient for investigating rare diseases and generating etiological hypotheses.
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ScholarGate方法对比: Risk-adjusted case-control study · Case-control study. 于 2026-06-15 检索自 https://scholargate.app/zh/compare