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领域科学计量学证据综合
方法族Process / pipelineProcess / pipeline
起源年份1990s–2015 (Cochrane established 1993; PROSPERO launched 2011; PRISMA-P 2015)2002
提出者Cochrane Collaboration; formalized through PROSPERO and PRISMA-P initiativesLumley (2002)
类型Evidence synthesis with pre-registered protocolMethod
开创性文献Higgins, J. P. T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M. J., & Welch, V. A. (Eds.). (2023). Cochrane Handbook for Systematic Reviews of Interventions (Version 6.4). Cochrane. link ↗Lumley, T. (2002). Network meta-analysis for indirect treatment comparisons. Statistics in Medicine, 21(16), 2313–2324. DOI ↗
别名pre-registered meta-analysis, prospective meta-analysis, registered meta-analysis, protocol-driven meta-analysisMixed Treatment Comparison, MTC, Indirect Comparison Meta-Analysis
相关41
摘要A protocol-based meta-analysis is a meta-analysis conducted according to a detailed, pre-registered protocol that specifies all key methodological decisions — research questions, eligibility criteria, search strategy, outcome measures, and statistical methods — before data collection begins. Pre-registration, typically through PROSPERO or a comparable registry, distinguishes this approach from post-hoc or exploratory meta-analyses and substantially reduces the risk of selective reporting and outcome switching.Network meta-analysis (NMA) is a systematic method for comparing multiple interventions simultaneously within a single analytical framework, incorporating both direct evidence (head-to-head trials) and indirect evidence (comparisons via common comparators). First formalized by Lumley in 2002, NMA allows researchers to rank treatments and quantify comparative effectiveness even when some treatment pairs have never been directly studied.
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ScholarGate方法对比: Protocol-based Meta-analysis · Network Meta-Analysis. 于 2026-06-17 检索自 https://scholargate.app/zh/compare