方法对比

	前瞻性病例对照研究	病例对照研究
领域	流行病学	流行病学
方法族	Process / pipeline	Process / pipeline
起源年份	1970s–1990s (formalized alongside nested case-control methods)	1950s (formal methodology); precursors in the 1920s
提出者	Evolved from classical retrospective case-control methodology; prospective embedding attributed to modern epidemiological practice (Rothman, Greenland, and others, late 20th century)	Janet Lane-Claypon (early precursors, 1926); formalized by Brian MacMahon and Jerome Cornfield in the 1950s–1960s
类型	Observational analytic study design	Observational analytic study design
开创性文献	Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641	Schlesselman, J.J. (1982). Case-Control Studies: Design, Conduct, Analysis. Oxford University Press. ISBN: 978-0195027860
别名	prospective case-control design, ambidirectional case-control, bidirectional case-control, nested case-control (prospective variant)	case-referent study, case-control design, retrospective case-control, case-control analysis
相关	6	6
摘要	A prospective case-control study embeds the case-control logic within a defined cohort followed forward in time. Cases are identified as they occur, rather than looked up in records after the fact, and controls are sampled from the same prospectively monitored base population. This forward-looking approach allows collection of exposure data before outcome ascertainment, reducing recall bias — the principal weakness of the classic retrospective case-control design — while retaining the efficiency gains of sampling controls rather than enrolling a full cohort.	A case-control study is a retrospective observational design in which individuals who have developed a disease or outcome of interest (cases) are compared with individuals who have not (controls) to determine whether prior exposure to a putative risk factor differs between the two groups. The primary measure of association is the odds ratio, which approximates the relative risk when the outcome is rare. Case-control studies are especially efficient for investigating rare diseases and generating etiological hypotheses.