方法对比

	实用性横断面流行病学研究	病例对照研究
领域	流行病学	流行病学
方法族	Process / pipeline	Process / pipeline
起源年份	Mid-20th century onwards; pragmatic framing prominent from 1967	1950s (formal methodology); precursors in the 1920s
提出者	Classical epidemiology tradition; pragmatic framing refined by Schwartz & Lellouch (1967) and subsequent real-world evidence literature	Janet Lane-Claypon (early precursors, 1926); formalized by Brian MacMahon and Jerome Cornfield in the 1950s–1960s
类型	Observational epidemiological design	Observational analytic study design
开创性文献	Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641	Schlesselman, J.J. (1982). Case-Control Studies: Design, Conduct, Analysis. Oxford University Press. ISBN: 978-0195027860
别名	pragmatic cross-sectional survey, real-world cross-sectional study, observational cross-sectional study, prevalence survey	case-referent study, case-control design, retrospective case-control, case-control analysis
相关	4	6
摘要	A pragmatic cross-sectional epidemiological study measures the prevalence of exposures, outcomes, and risk factors in a defined population at a single point in time, conducted under real-world conditions rather than tightly controlled experimental settings. It provides a snapshot of the health status of a community or patient group, making it one of the most widely used designs for surveillance, needs assessment, and hypothesis generation in clinical and public-health epidemiology.	A case-control study is a retrospective observational design in which individuals who have developed a disease or outcome of interest (cases) are compared with individuals who have not (controls) to determine whether prior exposure to a putative risk factor differs between the two groups. The primary measure of association is the odds ratio, which approximates the relative risk when the outcome is rare. Case-control studies are especially efficient for investigating rare diseases and generating etiological hypotheses.