方法对比

	优化辅助 Box-Behnken 设计	中心复合设计
领域	实验设计	实验设计
方法族	Process / pipeline	Process / pipeline
起源年份	1960 (BBD); optimization integration established 1980s–1990s	1951
提出者	Box & Behnken (design); Derringer & Suich (desirability optimization)	George E. P. Box and K. B. Wilson
类型	Experimental design with post-modeling optimization	Response surface experimental design
开创性文献	Box, G. E. P., & Behnken, D. W. (1960). Some new three level designs for the study of quantitative variables. Technometrics, 2(4), 455–475.	Box, G. E. P., & Wilson, K. B. (1951). On the experimental attainment of optimum conditions. Journal of the Royal Statistical Society: Series B, 13(1), 1–45.
别名	BBD with optimization, Box-Behnken design optimization, RSM-BBD optimization, Box-Behnken response optimization	CCD, Box-Wilson design, central composite response surface design, rotatable central composite design
相关	5	3
摘要	Optimization-assisted Box-Behnken design (BBD) combines the Box-Behnken three-level experimental design with a formal optimization step to locate factor settings that maximize, minimize, or hit a target for one or more responses. BBD fits a second-order response surface model using fewer runs than a full factorial, and the optimization stage — typically via desirability functions or numerical search — then exploits that fitted model to identify the true optimum within the experimental region.	Central Composite Design (CCD) is a second-order response surface design that allows researchers to efficiently fit a full quadratic model relating multiple continuous input factors to one or more response variables. Introduced by Box and Wilson in 1951, it combines a factorial (or fractional factorial) core, axial (star) points, and center-point replicates into a single unified design, making it the most widely used design for process optimization in engineering, chemistry, and manufacturing.