方法对比
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| 基于网络的代谢组学分析× | 蛋白质组学分析× | |
|---|---|---|
| 领域 | 生物信息学 | 生物信息学 |
| 方法族 | Process / pipeline | Process / pipeline |
| 起源年份≠ | 2005–2011 | 1994–2003 (term coined 1994; shotgun proteomics established early 2000s) |
| 提出者≠ | Barabasi, Loscalzo and colleagues (network medicine framework); Wishart and Xia (metabolomics network tools) | Marc Wilkins, Matthias Mann, Ruedi Aebersold (proteome/mass spectrometry foundations) |
| 类型≠ | Systems biology / omics analysis pipeline | Quantitative omics pipeline |
| 开创性文献≠ | Xia, J., & Wishart, D. S. (2010). MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data. Nucleic Acids Research, 38(Web Server issue), W71–W77. link ↗ | Wilkins, M. R., Sanchez, J.-C., Gooley, A. A., Appel, R. D., Humphery-Smith, I., Hochstrasser, D. F., & Williams, K. L. (1996). Progress with proteome projects: Why all proteins expressed by a genome should be identified and how to do it. Biotechnology and Genetic Engineering Reviews, 13(1), 19–50. link ↗ |
| 别名 | metabolic network analysis, systems metabolomics, network metabolomics, metabolite network enrichment | proteomics, mass spectrometry-based proteomics, shotgun proteomics, quantitative proteomics |
| 相关 | 6 | 6 |
| 摘要≠ | Network-based metabolomics analysis integrates quantitative metabolite profiling data with biological network structures — metabolic pathways, protein-metabolite interaction graphs, and disease networks — to reveal coordinated biochemical disruptions that individual metabolite lists would miss. Rather than treating each metabolite in isolation, this systems-level approach identifies modules, hubs, and perturbed subnetworks, providing mechanistic insight into how metabolic dysregulation propagates through cellular systems. | Proteomics analysis is a systematic pipeline for identifying and quantifying proteins in biological samples using mass spectrometry. Starting from raw spectral data, the workflow searches protein sequence databases, estimates abundance across conditions, applies statistical tests for differential expression, and maps findings onto biological pathways. It complements transcriptomics by capturing post-translational regulation and actual protein abundance, and is central to biomarker discovery, drug-target identification, and systems biology. |
| ScholarGate数据集 ↗ |
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