方法对比
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| 多中心诊断准确性研究× | 多中心队列研究× | |
|---|---|---|
| 领域 | 流行病学 | 流行病学 |
| 方法族 | Process / pipeline | Process / pipeline |
| 起源年份≠ | 2003 (STARD statement first published; updated 2015) | Mid-to-late 20th century (widespread adoption 1970s–1990s) |
| 提出者≠ | STARD Group (Bossuyt, Reitsma et al.) | Developed incrementally through large collaborative epidemiological projects (e.g., Framingham Heart Study consortium expansions, 1948 onward; EPIC study, 1992) |
| 类型≠ | Observational diagnostic study design | Observational longitudinal study |
| 开创性文献≠ | Bossuyt, P. M., Reitsma, J. B., Bruns, D. E., Gatsonis, C. A., Glasziou, P. P., Irwig, L., Lijmer, J. G., Moher, D., Rennie, D., de Vet, H. C. W., Kressel, H. Y., Rifai, N., Golub, R. M., Altman, D. G., Hooft, L., Korevaar, D. A., & Cohen, J. F. (2015). STARD 2015: An Updated List of Essential Items for Reporting Diagnostic Accuracy Studies. BMJ, 351, h5527. DOI ↗ | Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641 |
| 别名 | multisite diagnostic accuracy study, multicenter DTA study, multicenter index test evaluation, STARD multicenter study | multisite cohort study, multi-centre cohort, collaborative cohort study, pooled cohort study |
| 相关≠ | 5 | 6 |
| 摘要≠ | A multicenter diagnostic accuracy study evaluates how well an index test (e.g., a biomarker, imaging modality, or clinical prediction rule) identifies a target condition when conducted across two or more independent clinical sites. By recruiting patients from diverse settings, it produces estimates of sensitivity, specificity, and likelihood ratios that are more externally valid than those obtained from a single center, and it enables explicit assessment of how test performance varies across sites, patient populations, and operator skill levels. | A multicenter cohort study follows defined groups of participants at two or more geographically or institutionally distinct sites over time to estimate incidence, identify risk factors, and quantify associations between exposures and outcomes. By pooling data from multiple centers, it achieves statistical power and population diversity that single-site designs cannot match, making it the workhorse of large-scale epidemiological and clinical research. |
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