方法对比

	多中心Cox比例风险模型	Cox比例风险模型
领域	流行病学	流行病学
方法族	Process / pipeline	Process / pipeline
起源年份	1972 (Cox model); multicenter applications formalized 1980s–1990s	1972
提出者	D. R. Cox (Cox PH model); multicenter extension developed through collaborative trial methodology	Sir David Roxbee Cox
类型	Semi-parametric survival regression for clustered data	Semi-parametric regression model
开创性文献	Cox, D. R. (1972). Regression models and life-tables. Journal of the Royal Statistical Society: Series B (Methodological), 34(2), 187–202.	Cox, D. R. (1972). Regression models and life-tables. Journal of the Royal Statistical Society: Series B (Methodological), 34(2), 187–202.
别名	multicenter Cox regression, multisite Cox PH model, stratified Cox model across centers, multicenter survival regression	Cox regression, Cox PH model, proportional hazards model, CPH
相关	4	5
摘要	Multicenter Cox proportional hazards regression extends the classic Cox PH model to studies conducted at two or more clinical sites or centers. It estimates the effect of predictors on time-to-event outcomes while explicitly accounting for clustering within centers, between-center heterogeneity, and potential differences in baseline hazard across sites. This design is standard practice in large multicenter RCTs and observational cohort studies in oncology, cardiology, and other clinical fields.	The Cox proportional hazards model is a semi-parametric regression method that estimates the effect of one or more covariates on the hazard — the instantaneous rate of an event such as death, relapse, or failure — while making no assumption about the shape of the baseline hazard function. Introduced by David Cox in 1972, it is the dominant tool for multivariable survival analysis in clinical and epidemiological research.