方法对比

	多中心病例交叉设计	病例-交叉设计
领域	流行病学	流行病学
方法族	Process / pipeline	Process / pipeline
起源年份	1991 (core design); multicenter extensions 1990s–2000s	1991
提出者	Malcolm Maclure (single-center design, 1991); multicenter applications developed through 1990s–2000s environmental and pharmacoepidemiology literature	Malcolm Maclure
类型	Observational epidemiological design	Observational epidemiological study design
开创性文献	Maclure, M. (1991). The case-crossover design: A method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153.	Maclure, M. (1991). The case-crossover design: A method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153.
别名	multi-site case-crossover study, multicenter self-matched crossover, multi-center transient exposure study, MCCO study	case-crossover study, CCO design, self-matched case study, within-person crossover case study
相关	4	3
摘要	The multicenter case-crossover design is an observational epidemiological method that investigates whether brief, transient exposures trigger acute health events by comparing each case's exposure just before the event to their own exposure during matched control periods — with data collected from two or more independent clinical or geographic sites to increase power, external validity, and the ability to detect site-level effect modification.	The case-crossover design is an observational epidemiological method that estimates whether a transient exposure triggers an acute event by comparing each case's exposure during a brief hazard window immediately before the event to their own exposure during earlier control periods. Because each person serves as their own control, all stable personal characteristics are automatically adjusted for, making the design especially powerful for studying intermittent exposures and sudden-onset outcomes such as myocardial infarction, stroke, or injury.