方法对比
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| 代谢组学分析× | 蛋白质组学分析× | |
|---|---|---|
| 领域 | 生物信息学 | 生物信息学 |
| 方法族 | Process / pipeline | Process / pipeline |
| 起源年份≠ | 1998–2002 | 1994–2003 (term coined 1994; shotgun proteomics established early 2000s) |
| 提出者≠ | Oliver et al. (coining of 'metabolomics'); Oliver Fiehn (systematic framework) | Marc Wilkins, Matthias Mann, Ruedi Aebersold (proteome/mass spectrometry foundations) |
| 类型 | Quantitative omics pipeline | Quantitative omics pipeline |
| 开创性文献≠ | Fiehn, O. (2002). Metabolomics — the link between genotypes and phenotypes. Plant Molecular Biology, 48(1-2), 155–171. link ↗ | Wilkins, M. R., Sanchez, J.-C., Gooley, A. A., Appel, R. D., Humphery-Smith, I., Hochstrasser, D. F., & Williams, K. L. (1996). Progress with proteome projects: Why all proteins expressed by a genome should be identified and how to do it. Biotechnology and Genetic Engineering Reviews, 13(1), 19–50. link ↗ |
| 别名 | metabolome profiling, metabolic profiling, metabonomics, metabolite profiling | proteomics, mass spectrometry-based proteomics, shotgun proteomics, quantitative proteomics |
| 相关 | 6 | 6 |
| 摘要≠ | Metabolomics analysis is the large-scale, systematic measurement of small-molecule metabolites in a biological sample to characterise the metabolome — the complete set of metabolic intermediates and products present under defined conditions. By coupling high-throughput analytical platforms such as mass spectrometry (MS) or nuclear magnetic resonance (NMR) spectroscopy with multivariate statistics and pathway databases, metabolomics bridges the genotype–phenotype gap and captures the downstream functional output of genes, transcripts, and proteins in real time. | Proteomics analysis is a systematic pipeline for identifying and quantifying proteins in biological samples using mass spectrometry. Starting from raw spectral data, the workflow searches protein sequence databases, estimates abundance across conditions, applies statistical tests for differential expression, and maps findings onto biological pathways. It complements transcriptomics by capturing post-translational regulation and actual protein abundance, and is central to biomarker discovery, drug-target identification, and systems biology. |
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