方法对比

	荟萃分析病例对照研究	匹配病例对照研究
领域	流行病学	流行病学
方法族	Process / pipeline	Process / pipeline
起源年份	1980s–2000 (formalized with MOOSE reporting guidelines in 2000)	1950s–1970s
提出者	Systematic development attributed to multiple epidemiologists; MOOSE guidelines formalized by Stroup et al.	Brian MacMahon and others; systematised by Schlesselman (1982)
类型	Observational study synthesis	Observational analytic design
开创性文献	Shapiro, S. (1994). Meta-analysis/Shmeta-analysis. American Journal of Epidemiology, 140(9), 771-778.	Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755474
别名	pooled case-control analysis, case-control meta-analysis, meta-analytic case-control design, systematic pooled case-control	matched case-referent study, individually matched case-control, pair-matched case-control, matched case-control design
相关	4	5
摘要	A meta-analytic case-control study systematically identifies, critically appraises, and quantitatively synthesizes data from multiple independent case-control studies examining the same exposure-disease relationship. By pooling odds ratios across studies, it yields a more precise and generalizable estimate of association than any single study can provide, while formally quantifying heterogeneity across populations, settings, and study periods.	A matched case-control study is an observational epidemiological design in which each case (a person with the disease or outcome of interest) is paired with one or more controls (persons without the outcome) who share one or more characteristics — such as age, sex, or clinical setting — to control confounding. Exposure history is then compared between cases and their matched controls to estimate the odds ratio of the exposure-disease association.