方法对比

	机器学习辅助的微生物组多样性分析	多组学微生物多样性分析
领域	生物信息学	生物信息学
方法族	Process / pipeline	Process / pipeline
起源年份	2011–2016 (formalization of ML integration into microbiome pipelines)	2010s–present
提出者	Pasolli, Segata and colleagues (meta-ML framework); broader field grew from Turnbaugh et al. human microbiome work	Developed collectively; key frameworks by Le Cao et al. (mixOmics, 2017) and Argelaguet et al. (MOFA, 2018)
类型	Computational pipeline (supervised/unsupervised ML + diversity metrics)	Integrative computational pipeline
开创性文献	Pasolli, E., Truong, D. T., Malik, F., Waldron, L., & Segata, N. (2016). Machine Learning Meta-analysis of Large Metagenomic Datasets: Tools and Biological Insights. PLOS Computational Biology, 12(7), e1004977.	Rohart, F., Gautier, B., Singh, A., & Le Cao, K.-A. (2017). mixOmics: An R package for 'omics feature selection and multiple data integration. PLOS Computational Biology, 13(11), e1005752.
别名	ML-based microbiome analysis, supervised microbiome diversity, microbiome ML classification, ML-driven alpha/beta diversity analysis	multi-omics microbiome profiling, integrated microbiome omics, multi-modal microbiome analysis, microbiome multi-omics integration
相关	5	5
摘要	Machine learning-assisted microbiome diversity analysis integrates classical alpha and beta diversity metrics with supervised or unsupervised ML models to classify host phenotypes, identify discriminant taxa, and uncover community-level signatures from 16S rRNA or shotgun metagenomic data. It extends traditional diversity analysis beyond descriptive statistics toward predictive and explanatory modelling across health, ecology, and environmental science.	Multi-omics microbiome diversity analysis integrates two or more omic data layers — such as metagenomics, metatranscriptomics, metabolomics, and metaproteomics — to characterise both the composition and functional activity of microbial communities. By linking taxonomic diversity metrics with molecular phenotype data, the approach uncovers how community structure translates into ecological and host-relevant functions that no single omic layer can reveal alone.