方法对比

	双盲分数析因实验	响应面方法 (RSM)
领域	实验设计	实验设计
方法族	Process / pipeline	Hypothesis test
起源年份	1960s onward (combination widely used in pharmaceutical and food science research)	1951
提出者	Fractional factorial: Box & Hunter (1961); double-blind convention: clinical trial methodology (mid-20th century)	George E. P. Box & K. B. Wilson
类型	Controlled experimental design with blinding and factor-space reduction	Second-order polynomial response surface model
开创性文献	Box, G. E. P., Hunter, J. S., & Hunter, W. G. (2005). Statistics for Experimenters: Design, Innovation, and Discovery (2nd ed.). Wiley-Interscience. ISBN: 978-0471718130	Box, G. E. P. & Wilson, K. B. (1951). On the experimental attainment of optimum conditions. Journal of the Royal Statistical Society, Series B, 13(1), 1–45.
别名	double-blind FFE, blinded fractional factorial design, double-blind FFD, masked fractional factorial experiment	RSM, Central Composite Design, Box-Behnken Design, CCD
相关	3	7
摘要	A double-blind fractional factorial experiment combines two powerful methodological protections: fractional factorial design, which tests a carefully chosen subset of all possible factor combinations to achieve efficiency, and double-blind administration, which prevents both participants and assessors from knowing which treatment combination has been applied. The result is an experiment that is both resource-efficient and protected against expectation and assessment bias.	Response Surface Methodology is a collection of statistical and mathematical techniques for building an empirical second-order polynomial model that relates a continuous response variable to two or more controllable input factors, and then locating the factor settings that optimize that response. The approach was introduced by George E. P. Box and K. B. Wilson in their landmark 1951 paper and has since become a cornerstone of process optimization across engineering, chemistry, food science, and pharmaceutics.