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| 剂量-反应实验设计与分析× | 单因素方差分析× | |
|---|---|---|
| 领域≠ | 实验设计 | 统计学 |
| 方法族 | Hypothesis test | Hypothesis test |
| 起源年份≠ | 1994 | 1925 |
| 提出者≠ | Classical pharmacology; formalized by ICH E4 (1994) and Ritz et al. (2015) | Ronald A. Fisher |
| 类型≠ | Nonlinear curve fitting and monotone contrast testing | Parametric mean comparison |
| 开创性文献≠ | Ritz, C., Baty, F., Streibig, J. C., & Gerhard, D. (2015). Dose-Response Analysis Using R. PLOS ONE, 10(12), e0146021. DOI ↗ | Fisher, R. A. (1925). Statistical Methods for Research Workers. Edinburgh: Oliver and Boyd. link ↗ |
| 别名≠ | dose-response analysis, dose-response curve, Doz-Yanıt Tasarımı ve Analizi (Dose-Response), ED50 analysis | one-factor ANOVA, single-factor ANOVA, analysis of variance, tek yönlü ANOVA |
| 相关 | 4 | 4 |
| 摘要≠ | Dose-response design is a framework for planning and analysing experiments that characterise the relationship between the amount of a stimulus — such as a drug dose or a chemical concentration — and the magnitude of a biological or physiological response. Formalised in regulatory guidance by the ICH E4 guideline (1994) and extensively developed in the statistical literature by Ritz et al. (2015), the framework covers experiment design, four-parameter and five-parameter logistic curve fitting, key benchmark estimates (ED50/EC50, NOAEL, LOAEL), and monotone trend testing via the Williams procedure. | One-way ANOVA is a parametric hypothesis test that compares the means of three or more independent groups on a single continuous outcome to decide whether at least one group mean differs. It rests on the variance-partitioning framework introduced by Ronald A. Fisher in 1925. |
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