方法对比

	交叉所罗门四组设计	交叉随机对照试验
领域	实验设计	实验设计
方法族	Process / pipeline	Process / pipeline
起源年份	1949 (base design); crossover adaptation developed through later methodological literature	1960s (Grizzle 1965 for statistical foundations); widely used in clinical research since the 1970s
提出者	Richard L. Solomon (base design); crossover extension via repeated-measures methodology	Early formalized by statisticians including Bradford Hill and colleagues in clinical trials; theoretical framework developed by Grizzle (1965) and later Senn (2002)
类型	Experimental design (pretest-sensitization control + within-subjects crossover)	Experimental within-subject design
开创性文献	Solomon, R. L. (1949). An extension of control group design. Psychological Bulletin, 46(2), 137–150.	Senn, S. (2002). Cross-over Trials in Clinical Research (2nd ed.). Wiley. ISBN: 978-0471496533
别名	crossover S4G design, within-subjects Solomon design, repeated-measures Solomon four-group design	crossover RCT, crossover trial, within-subject RCT, AB/BA crossover design
相关	5	5
摘要	The Crossover Solomon Four-Group Design merges two powerful experimental strategies: the Solomon four-group design's control for pretest sensitization and the crossover design's within-subjects efficiency. Participants are randomly assigned to one of four groups that vary in whether they receive a pretest and in the sequence of treatment and control conditions, allowing the researcher to simultaneously estimate treatment effects, pretest effects, and their interaction while controlling for individual differences through repeated measurement.	A crossover randomized controlled trial (crossover RCT) is an experimental design in which each participant receives all study interventions in a randomized sequence, separated by a washout period. Because every participant serves as their own control, within-subject variability is eliminated from the treatment comparison, yielding greater statistical power per participant than a parallel-group RCT of equal size.