方法对比

	交叉全因子实验	交叉随机对照试验
领域	实验设计	实验设计
方法族	Process / pipeline	Process / pipeline
起源年份	Mid-to-late 20th century (crossover trials formalised ~1960s–1980s; full factorial DoE from Fisher ~1935)	1960s (Grizzle 1965 for statistical foundations); widely used in clinical research since the 1970s
提出者	Developed within the design-of-experiments tradition (R. A. Fisher and successors); crossover adaptation formalised by B. Jones and M. G. Kenward	Early formalized by statisticians including Bradford Hill and colleagues in clinical trials; theoretical framework developed by Grizzle (1965) and later Senn (2002)
类型	Within-subject full factorial experimental design	Experimental within-subject design
开创性文献	Jones, B., & Kenward, M. G. (2003). Design and Analysis of Cross-Over Trials (2nd ed.). Chapman and Hall/CRC. ISBN: 978-1584883429	Senn, S. (2002). Cross-over Trials in Clinical Research (2nd ed.). Wiley. ISBN: 978-0471496533
别名	within-subject full factorial design, repeated-measures full factorial experiment, crossover factorial trial, full factorial crossover design	crossover RCT, crossover trial, within-subject RCT, AB/BA crossover design
相关	6	5
摘要	A crossover full factorial experiment combines the efficiency of a crossover (within-subject) design with the comprehensiveness of a full factorial design. Every participant receives all combinations of the factor levels across successive treatment periods, separated by washout intervals, allowing complete estimation of all main effects and interactions while using each participant as their own control.	A crossover randomized controlled trial (crossover RCT) is an experimental design in which each participant receives all study interventions in a randomized sequence, separated by a washout period. Because every participant serves as their own control, within-subject variability is eliminated from the treatment comparison, yielding greater statistical power per participant than a parallel-group RCT of equal size.