方法对比

	教育研究中的贝叶斯表观基因组全关联研究	孟德尔随机化
领域	生物信息学	因果推断
方法族	Process / pipeline	Regression model
起源年份	EWAS framework ~2010–2011; Bayesian EWAS variants ~2013–2017; educational applications ~2015–present	1997
提出者	Rakyan, Down, Balding, and Beck (conceptual EWAS framework); Bayesian extensions by multiple groups including Teschendorff and colleagues	George Davey Smith
类型	Genomic association study with Bayesian inference	Genetic instrumental variable framework
开创性文献	Rakyan, V. K., Down, T. A., Balding, D. J., & Beck, S. (2011). Epigenome-wide association studies for common human diseases. Nature Reviews Genetics, 12(8), 529–541.	Davey Smith, G., & Hemani, G. (2014). Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Human Molecular Genetics, 23(R1), R89-R98.
别名	Bayesian EWAS, Bayesian epigenome-wide scan, Bayesian methylation-wide association study, B-EWAS	MR
相关	3	2
摘要	A Bayesian epigenome-wide association study (Bayesian EWAS) scans hundreds of thousands of DNA methylation sites across the genome to identify those statistically associated with an educational outcome — such as cognitive ability, attainment, or socioeconomic exposure during schooling. Unlike classical frequentist EWAS, the Bayesian framework incorporates prior biological knowledge to compute posterior probabilities of association, improving power and reducing false discoveries when applied to complex educational phenotypes.	Mendelian randomization is a method for estimating causal effects of exposures on outcomes using genetic variants as instrumental variables. Introduced by George Davey Smith in the 1990s, it exploits Mendel's law of segregation to remove confounding bias. It has become a cornerstone technique in epidemiological causal inference.