方法对比
并排查看您选择的方法；存在差异的行会高亮显示。
| 自适应随机对照试验× | 顺序分析（分组顺序设计）× | |
|---|---|---|
| 领域≠ | 实验设计 | 统计学 |
| 方法族≠ | Process / pipeline | Hypothesis test |
| 起源年份≠ | 1980s–2000s (formalized; earlier sequential testing roots from Wald, 1947) | 1977 |
| 提出者≠ | Donald Berry and others; foundational adaptive trial methods developed through 1980s–2000s biostatistics literature | P. C. O'Brien & T. R. Fleming; P. C. Pocock |
| 类型≠ | Experimental design — adaptive variant of RCT | Sequential / adaptive hypothesis test |
| 开创性文献≠ | Chow, S.-C., & Chang, M. (2008). Adaptive Design Methods in Clinical Trials. Chapman & Hall/CRC. ISBN: 978-1584887690 | O'Brien, P.C. & Fleming, T.R. (1979). A Multiple Testing Procedure for Clinical Trials. Biometrics, 35(3), 549–556. DOI ↗ |
| 别名 | Adaptive RCT, Response-adaptive RCT, Adaptive clinical trial, Platform trial | sequential testing, group sequential design, interim analysis, Sıralı Analiz (Sequential Testing / Group Sequential Design) |
| 相关≠ | 6 | 5 |
| 摘要≠ | An adaptive randomized controlled trial (adaptive RCT) is an experimental design in which pre-specified rules allow modifications to the trial while it is ongoing — such as changing allocation ratios, dropping underperforming arms, or stopping early for efficacy or futility — based on accumulating interim data. These adaptations are planned before the trial starts and governed by statistical rules to preserve Type I error control and validity. | Sequential analysis is a framework for conducting hypothesis tests with pre-planned interim looks at accumulating data, allowing a study to stop early for efficacy or futility while controlling the overall Type I error rate. The group sequential approach was formalised by Pocock (1977) and O'Brien and Fleming (1979), and remains the standard for confirmatory clinical trials and rigorous A/B experiments. |
| ScholarGate数据集 ↗ |
|
|