方法对比
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| 自适应实验室实验× | 顺序分析（分组顺序设计）× | |
|---|---|---|
| 领域≠ | 实验设计 | 统计学 |
| 方法族≠ | Process / pipeline | Hypothesis test |
| 起源年份≠ | 1947 (sequential analysis foundations); adaptive laboratory applications widespread from 1990s | 1977 |
| 提出者≠ | Rooted in sequential analysis (Abraham Wald, 1947); adaptive clinical/lab designs formalized by Berry and colleagues (1990s–2000s) | P. C. O'Brien & T. R. Fleming; P. C. Pocock |
| 类型≠ | Adaptive experimental design | Sequential / adaptive hypothesis test |
| 开创性文献≠ | Berry, D. A. (2006). Bayesian clinical trials. Nature Reviews Drug Discovery, 5(1), 27–36. DOI ↗ | O'Brien, P.C. & Fleming, T.R. (1979). A Multiple Testing Procedure for Clinical Trials. Biometrics, 35(3), 549–556. DOI ↗ |
| 别名 | adaptive lab experiment, sequential adaptive laboratory study, response-adaptive laboratory design, adaptive experimental laboratory design | sequential testing, group sequential design, interim analysis, Sıralı Analiz (Sequential Testing / Group Sequential Design) |
| 相关 | 5 | 5 |
| 摘要≠ | An adaptive laboratory experiment is a controlled experimental design conducted in a laboratory setting where pre-specified decision rules allow modifications to the study — such as sample size, treatment allocation, or stopping criteria — based on accumulating data. Unlike fixed designs, adaptive designs incorporate planned interim analyses that permit the experiment to respond to emerging evidence while maintaining statistical validity and Type I error control. | Sequential analysis is a framework for conducting hypothesis tests with pre-planned interim looks at accumulating data, allowing a study to stop early for efficacy or futility while controlling the overall Type I error rate. The group sequential approach was formalised by Pocock (1977) and O'Brien and Fleming (1979), and remains the standard for confirmatory clinical trials and rigorous A/B experiments. |
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