So sánh phương pháp

	Phân tích Chuyển hóa Dữ liệu Bayes	Phân tích làm giàu đường dẫn
Lĩnh vực	Tin sinh học	Tin sinh học
Họ	Process / pipeline	Process / pipeline
Năm ra đời	2005–2010	2003–2005
Người khởi xướng	Simon Rogers, Mark Girolami and colleagues (Bayesian NMR metabolomics framework, ~2009); broader Bayesian metabolomics developed through 2000s–2010s	Mootha et al. (2003); systematised by Subramanian et al. (2005)
Loại	Probabilistic statistical pipeline	Statistical functional annotation method
Công trình gốc	Rogers, S., Scheltema, R. A., & Girolami, M. A. (2009). Bayesian analysis of metabolomic NMR data. Bioinformatics, 25(14), 1809-1815.	Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., & Mesirov, J. P. (2005). Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences, 102(43), 15545–15550.
Tên gọi khác	Bayesian metabolomics, probabilistic metabolomics, Bayesian metabolite profiling, Bayesian metabolic flux analysis	PEA, overrepresentation analysis, ORA, functional enrichment analysis
Liên quan	6	6
Tóm tắt	Bayesian metabolomics analysis applies probabilistic inference to metabolite abundance data — typically from mass spectrometry or NMR spectroscopy — to identify differentially abundant metabolites, annotate spectral features, and integrate pathway knowledge. By encoding prior biological knowledge into prior distributions and propagating uncertainty throughout the analysis, it yields more calibrated probability statements about metabolic differences than classical frequentist testing alone.	Pathway enrichment analysis (PEA) is a statistical approach that takes a list of genes or proteins of interest — typically derived from a differential expression or proteomics experiment — and identifies which pre-defined biological pathways or functional gene sets are represented more often than expected by chance. By mapping individual molecular changes onto curated pathway knowledge bases such as KEGG, Gene Ontology, or Reactome, PEA translates long gene lists into interpretable biological processes, making it a central tool in the post-analysis of high-throughput omics experiments.