Process / pipelineIn vivo angiogenesis model
CAM Assay
The chorioallantoic membrane (CAM) assay is a well-established in vivo model for studying angiogenesis (new blood vessel formation) and evaluating the pro- or anti-angiogenic properties of biomaterials, drugs, and bioactive molecules. Developed by Judah Folkman in the 1970s, the assay uses the highly vascularized CAM of developing chick embryos as a platform for implanting test materials and observing vascular response. The CAM provides a transparent, immunologically naive microenvironment with rapid and reproducible neovascularization, making it ideal for screening angiogenic potential and assessing biomaterial biocompatibility.
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Sources
- Folkman, J. (1974). Tumor angiogenesis: therapeutic implications. New England Journal of Medicine, 285(21), 1182-1186. DOI: 10.1056/NEJM197405162852108 ↗
- Ribatti, D. (2016). The chick embryo chorioallantoic membrane (CAM) assay. Current Protocols in Immunology, 15, 12.1-12.13. DOI: 10.1002/cpim.3 ↗
- Norris, C. S., Griffith, O. W., & Reid, L. M. (2003). The chorioallantoic membrane (CAM) as a model for angiogenesis. In Antiangiogenic Agents in Cancer Therapy. Humana Press, pp. 463-477. DOI: 10.1385/1-59259-413-X:463 ↗