เปรียบเทียบวิธี

	SAXS	ATR-FTIR	Extended X-ray Absorption Fine Structure (EXAFS)
สาขาวิชา	สเปกโทรสโกปี	สเปกโทรสโกปี	สเปกโทรสโกปี
ตระกูล	Process / pipeline	Process / pipeline	Process / pipeline
ปีกำเนิด	1954	1961	1971
ผู้ริเริ่ม	Otto Kratky	Joop Fahrenfort	Edward Stern
ประเภท	Synchrotron/X-ray technique	Vibrational spectroscopy technique	Synchrotron technique
แหล่งต้นตำรับ	Glatter, O., & Kratky, O. (1982). Small Angle X-ray Scattering. Academic Press.	Harrick, N. J. (1960). Study of physics of internal reflection from metals. Journal of Physics and Chemistry of Solids, 13(2), 143-155.	Sayers, D. E., Stern, E. A., & Lytle, F. W. (1971). New technique for investigating noncrystalline structures: Fourier analysis of the extended X-ray absorption fine structure. Physical Review Letters, 27(18), 1204-1207.
ชื่อเรียกอื่น	SAXS, small-angle scattering	ATR-IR, attenuated total reflectance, FTIR spectroscopy	EXAFS spectroscopy, X-ray absorption spectroscopy
ที่เกี่ยวข้อง	3	3	3
สรุป	Small-Angle X-ray Scattering (SAXS) is a solution-phase X-ray scattering technique that measures the overall shape and size of macromolecules and nanoparticles by analyzing scattering intensity at low angles (0.1-10 degrees). Developed by Kratky and colleagues in the 1950s, SAXS provides information about molecular radius, aggregation state, and overall shape without requiring crystallization or fixing, making it ideal for studying native protein conformations and dynamics.	Attenuated Total Reflectance (ATR) Fourier Transform Infrared (FTIR) spectroscopy is a variant of conventional FTIR that measures infrared absorption through evanescent-wave interrogation of samples in direct contact with a high-refractive-index crystal. Developed by Harrick and Fahrenfort in the 1960s, ATR-FTIR is now the dominant form of FTIR spectroscopy, enabling rapid, non-destructive characterization of organic compounds, polymers, coatings, and biological materials without extensive sample preparation.	Extended X-ray Absorption Fine Structure (EXAFS) is a synchrotron-based X-ray spectroscopy technique that measures the local geometric and electronic structure around a specific atom in any material, crystal or amorphous. Discovered by Sayers, Stern, and Lytle in 1971, EXAFS reveals interatomic distances, coordination numbers, and disorder in the atomic environment by analyzing oscillations in the X-ray absorption spectrum above an absorption edge.