เปรียบเทียบวิธี

	การออกแบบการทดลองที่เหมาะสมที่สุด (D-Optimal, I-Optimal)	Central Composite Design
สาขาวิชา	การออกแบบการทดลอง	การออกแบบการทดลอง
ตระกูล	Hypothesis test	Process / pipeline
ปีกำเนิด	1972	1951
ผู้ริเริ่ม	V. V. Fedorov	George E. P. Box and K. B. Wilson
ประเภท	Computer-aided optimal design	Response surface experimental design
แหล่งต้นตำรับ	Fedorov, V.V. (1972). Theory of Optimal Experiments. Academic Press.	Box, G. E. P., & Wilson, K. B. (1951). On the experimental attainment of optimum conditions. Journal of the Royal Statistical Society: Series B, 13(1), 1–45.
ชื่อเรียกอื่น	D-Optimal Design, I-Optimal Design, Computer-Generated Design, Optimal Deneme Deseni (D-Optimal, I-Optimal)	CCD, Box-Wilson design, central composite response surface design, rotatable central composite design
ที่เกี่ยวข้อง	5	3
สรุป	Optimal experimental design is a computer-aided approach to constructing experiments that maximises statistical efficiency for a given model and run budget. Formalised by V. V. Fedorov in 1972, it selects experimental points from a candidate set so that the information matrix M = X'X is optimised according to a chosen criterion — most commonly D-optimality (maximising the determinant) or I-optimality (minimising average prediction variance). It is the preferred strategy whenever classical designs such as central composite or Box-Behnken cannot be applied because the experimental region is constrained or factor ranges are irregular.	Central Composite Design (CCD) is a second-order response surface design that allows researchers to efficiently fit a full quadratic model relating multiple continuous input factors to one or more response variables. Introduced by Box and Wilson in 1951, it combines a factorial (or fractional factorial) core, axial (star) points, and center-point replicates into a single unified design, making it the most widely used design for process optimization in engineering, chemistry, and manufacturing.