เปรียบเทียบวิธี

	การทดลองทางคลินิกระยะที่ II แบบอภิมาน (Meta-analytic Phase II Clinical Trial)	การวิเคราะห์อภิมานเครือข่าย
สาขาวิชา	ระบาดวิทยา	การสังเคราะห์หลักฐาน
ตระกูล	Process / pipeline	Process / pipeline
ปีกำเนิด	2000s–2010s	2002
ผู้ริเริ่ม	Developed within clinical epidemiology and oncology statistics; key contributions by Sutton, Warmuth, and colleagues	Lumley (2002)
ประเภท	Hybrid clinical trial / meta-analytic design	Method
แหล่งต้นตำรับ	Warmuth, M., & Hinzmann, B. (2013). Phase II trials in oncology: From the statistical design of trials to the meta-analysis of the results. Onkologie, 36(9), 555–564.	Lumley, T. (2002). Network meta-analysis for indirect treatment comparisons. Statistics in Medicine, 21(16), 2313–2324.
ชื่อเรียกอื่น	MA-Phase II, meta-analytic single-arm trial, pooled Phase II design, Phase II meta-analysis	Mixed Treatment Comparison, MTC, Indirect Comparison Meta-Analysis
ที่เกี่ยวข้อง	2	1
สรุป	A meta-analytic Phase II clinical trial integrates individual or aggregate data from multiple single-arm or small Phase II studies into a unified meta-analytic framework. Rather than relying on a single underpowered trial to screen for activity, this design pools evidence across comparable cohorts to obtain a more reliable estimate of treatment response, enabling better-informed go/no-go decisions before committing to a large Phase III randomized trial.	Network meta-analysis (NMA) is a systematic method for comparing multiple interventions simultaneously within a single analytical framework, incorporating both direct evidence (head-to-head trials) and indirect evidence (comparisons via common comparators). First formalized by Lumley in 2002, NMA allows researchers to rank treatments and quantify comparative effectiveness even when some treatment pairs have never been directly studied.