Linganisha mbinu

	Utoaji wa Dawa kwa Njia ya Liposomal	Kipimo cha Upenyezaji wa Seli za Caco-2
Nyanja	Famakolojia	Famakolojia
Familia	Process / pipeline	Process / pipeline
Mwaka wa asili	1965	1989
Mwanzilishi	Alec Bangham	Ingrid Hidalgo
Aina	formulation technology	absorption screening
Chanzo asilia	Bangham, A. D., Standish, M. M., & Watkins, J. C. (1965). Diffusion of univalent ions across the lamellae of swollen phospholipid films and the determination of membrane potential. Journal of Molecular Biology, 13(1), 238-252.	Hidalgo, I. J., Raub, T. J., & Borchardt, R. T. (1989). Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96(3), 736-749.
Majina mbadala	liposomal formulation, vesicular delivery, lipid nanoparticles	Caco-2 assay, intestinal permeability, ADME screening
Zinazohusiana	3	3
Muhtasari	Liposomal encapsulation is a formulation technique using lipid bilayer vesicles (liposomes) to enclose drugs, improving bioavailability, reducing toxicity, and enabling targeted delivery. Developed by Alec Bangham in 1965, liposomes are now standard in pharmaceutical development, with several FDA-approved liposomal drugs on the market.	The Caco-2 assay is an in vitro model system using human colon carcinoma cell monolayers to screen drug intestinal permeability. Developed by Hidalgo and colleagues in 1989, Caco-2 cells differentiate into an epithelial barrier resembling intestinal mucosa, enabling rapid assessment of drug absorption potential and identification of transporter-mediated transport.