Comparar métodos
Examine os métodos selecionados lado a lado; as linhas que diferem ficam destacadas.
| Reconstrução por Crio-EM× | Topologia de Rede de Interação Proteína-Proteína× | |
|---|---|---|
| Área | Bioinformática | Bioinformática |
| Família | Process / pipeline | Process / pipeline |
| Ano de origem≠ | 1975 | 2000 |
| Autor original≠ | Joachim Frank | Peter Uetz |
| Tipo≠ | Image reconstruction pipeline | Network analysis pipeline |
| Fonte seminal≠ | Frank, J. (2002). Single-particle imaging of macromolecules by cryo-electron microscopy. Annual Review of Biophysics and Biomolecular Structure, 31, 303-319. DOI ↗ | Uetz, P., Giot, L., Cagney, G., Mansfield, T. A., Judson, R. S., Knight, J. R., ... & Lomax, J. (2000). A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature, 403(6770), 623-627. DOI ↗ |
| Outros nomes | cryo-electron microscopy, cryo-EM, single-particle cryo-EM | protein interaction networks, interactome analysis, network topology |
| Relacionados | 3 | 3 |
| Resumo≠ | Cryo-electron microscopy (cryo-EM) determines three-dimensional macromolecular structures at atomic or near-atomic resolution by imaging proteins frozen in vitreous ice. Pioneered by Frank, Henderson, and others, this technique has revolutionized structural biology by enabling visualization of large, non-crystallizable complexes and capturing functional conformational states. | Protein-protein interaction network analysis identifies and characterizes the structural properties of cellular interaction networks. Pioneered by Uetz and colleagues through large-scale yeast two-hybrid screening, this approach reveals topological features like hubs, modules, and motifs that encode functional organization and disease associations. |
| ScholarGateConjunto de dados ↗ |
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