Sammenlign metoder

	Bayesian genesettberikelsesanalyse	Pathway Enrichment Analysis
Fagfelt	Bioinformatikk	Bioinformatikk
Familie	Process / pipeline	Process / pipeline
Opprinnelsesår	2004–2007	2003–2005
Opphavsperson	Michael A. Newton, Frank A. Quintana and colleagues; building on Subramanian et al. GSEA framework	Mootha et al. (2003); systematised by Subramanian et al. (2005)
Type	Probabilistic gene set enrichment method	Statistical functional annotation method
Opprinnelig kilde	Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., ... & Mesirov, J. P. (2005). Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences, 102(43), 15545-15550.	Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., & Mesirov, J. P. (2005). Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences, 102(43), 15545–15550.
Alias	Bayesian GSEA, BGSEA, Bayesian pathway scoring, probabilistic gene set testing	PEA, overrepresentation analysis, ORA, functional enrichment analysis
Relaterte	6	6
Sammendrag	Bayesian gene set enrichment analysis (Bayesian GSEA) applies a probabilistic framework to determine whether predefined sets of genes — representing biological pathways, cellular processes, or functional categories — are collectively more differentially expressed than expected by chance. Unlike classical frequentist GSEA, the Bayesian approach models uncertainty in expression estimates explicitly, incorporates prior biological knowledge, and produces posterior probabilities of enrichment rather than raw p-values, enabling more principled inference especially in small-sample settings.	Pathway enrichment analysis (PEA) is a statistical approach that takes a list of genes or proteins of interest — typically derived from a differential expression or proteomics experiment — and identifies which pre-defined biological pathways or functional gene sets are represented more often than expected by chance. By mapping individual molecular changes onto curated pathway knowledge bases such as KEGG, Gene Ontology, or Reactome, PEA translates long gene lists into interpretable biological processes, making it a central tool in the post-analysis of high-throughput omics experiments.