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Adaptivt kontrollert randomisert studie×Bayesiansk inferens×
FagfeltForsøksdesignStatistikk
FamilieProcess / pipelineBayesian methods
Opprinnelsesår1980s–2000s (formalized; earlier sequential testing roots from Wald, 1947)1763
OpphavspersonDonald Berry and others; foundational adaptive trial methods developed through 1980s–2000s biostatistics literatureThomas Bayes; Pierre-Simon Laplace
TypeExperimental design — adaptive variant of RCTProbabilistic inference paradigm
Opprinnelig kildeChow, S.-C., & Chang, M. (2008). Adaptive Design Methods in Clinical Trials. Chapman & Hall/CRC. ISBN: 978-1584887690Bayes, T. (1763). An essay towards solving a problem in the doctrine of chances. Philosophical Transactions of the Royal Society of London, 53, 370–418. link ↗
AliasAdaptive RCT, Response-adaptive RCT, Adaptive clinical trial, Platform trialBayes inference, Bayesian statistics, Bayesian updating, posterior inference
Relaterte63
SammendragAn adaptive randomized controlled trial (adaptive RCT) is an experimental design in which pre-specified rules allow modifications to the trial while it is ongoing — such as changing allocation ratios, dropping underperforming arms, or stopping early for efficacy or futility — based on accumulating interim data. These adaptations are planned before the trial starts and governed by statistical rules to preserve Type I error control and validity.Bayesian inference is a statistical paradigm in which probability represents degrees of belief rather than long-run frequencies. It encodes prior knowledge about parameters in a prior distribution, combines that prior with the likelihood of observed data via Bayes' theorem, and produces a posterior distribution that quantifies updated uncertainty. The foundational theorem was published posthumously by Thomas Bayes in 1763 and subsequently systematized by Pierre-Simon Laplace in his 1812 Théorie analytique des probabilités.
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ScholarGateSammenlign metoder: Adaptive Randomized Controlled Trial · Bayesian Inference. Hentet 2026-06-17 fra https://scholargate.app/no/compare