Methoden vergelijken

	Cox-regressie met tijdsvariërende covariaten	Shared Frailty Model voor Geklusterde Overlevingsdata
Vakgebied	Overlevingsanalyse	Overlevingsanalyse
Familie	Survival analysis	Survival analysis
Jaar van ontstaan	1972	1979
Grondlegger	Cox, D. R. (extended formulation by Therneau & Grambsch)	Vaupel, J.W., Manton, K.G. & Stallard, E.
Type	Semi-parametric hazard regression model	Random effects survival model
Oorspronkelijke bron	Therneau, T. M. & Grambsch, P. M. (2000). Modeling Survival Data: Extending the Cox Model. Springer.	Vaupel, J.W., Manton, K.G. & Stallard, E. (1979). The Impact of Heterogeneity in Individual Frailty on the Dynamics of Mortality. Demography, 16(3), 439–454.
Aliassen	time-varying covariate Cox model, extended Cox model, Zamana Bağlı Kovaryatlı Cox Regresyonu	shared frailty model, random effects survival model, Frailty Modeli (Paylaşılan Kırılganlık)
Verwant	4	3
Samenvatting	Time-dependent Cox regression is an extension of the standard Cox proportional hazards model, introduced through the counting-process formulation developed by Therneau and Grambsch (2000), that allows one or more predictor variables to take different values at different points in a subject's follow-up period. It is the method of choice whenever a covariate — such as a laboratory measurement, a medication dose, or a disease severity score — changes over time rather than remaining fixed from study entry.	The shared frailty model, introduced by Vaupel, Manton, and Stallard in 1979, extends standard survival regression by incorporating a random effect — the 'frailty' — that captures unobserved heterogeneity among subjects or clusters. When survival outcomes are measured on individuals who share a common environment (patients in the same hospital, members of the same family, animals in the same litter), a frailty term accounts for the within-cluster dependence that ordinary Cox regression ignores.