Methoden vergelijken

	Mendeliaanse Randomisatie	Regressiediscontinuïteitsontwerp (RDD)
Vakgebied	Causale inferentie	Causale inferentie
Familie	Regression model	Regression model
Jaar van ontstaan	1997	2008
Grondlegger	George Davey Smith	Imbens & Lemieux (guide to practice); Cattaneo, Idrobo & Titiunik (practical introduction)
Type	Genetic instrumental variable framework	Quasi-experimental causal design
Oorspronkelijke bron	Davey Smith, G., & Hemani, G. (2014). Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Human Molecular Genetics, 23(R1), R89-R98.	Imbens, G. W., & Lemieux, T. (2008). Regression Discontinuity Designs: A Guide to Practice. Journal of Econometrics, 142(2), 615-635.
Aliassen	MR	RDD, regression discontinuity design, sharp RDD, fuzzy RDD
Verwant	2	5
Samenvatting	Mendelian randomization is a method for estimating causal effects of exposures on outcomes using genetic variants as instrumental variables. Introduced by George Davey Smith in the 1990s, it exploits Mendel's law of segregation to remove confounding bias. It has become a cornerstone technique in epidemiological causal inference.	Regression Discontinuity Design is a quasi-experimental method that identifies a causal effect by locally comparing units just above and just below a cutoff on a continuous assignment (running) variable. Formalised for applied work by Imbens and Lemieux (2008) and developed as a practical framework by Cattaneo, Idrobo, and Titiunik (2020), it estimates a local average treatment effect (LATE) at the threshold.