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Model Gabungan untuk Data Longitudinal dan Masa-ke-Peristiwa×Regresi Cox dengan Kovariat yang Berubah Mengikut Masa×
BidangAnalisis SurvivalAnalisis Survival
KeluargaSurvival analysisSurvival analysis
Tahun asal20041972
PengasasTsiatis, A.A. & Davidian, M.; Rizopoulos, D.Cox, D. R. (extended formulation by Therneau & Grambsch)
JenisSemiparametric regression modelSemi-parametric hazard regression model
Sumber perintisRizopoulos, D. (2012). Joint Models for Longitudinal and Time-to-Event Data. CRC Press. DOI ↗Therneau, T. M. & Grambsch, P. M. (2000). Modeling Survival Data: Extending the Cox Model. Springer. DOI ↗
Aliasjoint model, shared random effects model, longitudinal-survival joint model, Joint Model (Boylamsal + Sağkalım Birleşik Model)time-varying covariate Cox model, extended Cox model, Zamana Bağlı Kovaryatlı Cox Regresyonu
Berkaitan54
RingkasanThe joint model for longitudinal and time-to-event data, formalised by Tsiatis and Davidian in 2004 and extended comprehensively by Rizopoulos in 2012, simultaneously estimates a mixed-effects model for repeatedly measured biomarkers and a survival model for the time to an event, linking the two processes through shared random effects. It resolves two major problems that simpler approaches cannot handle: informative dropout from longitudinal studies and the endogeneity of time-varying biomarkers used as covariates in a Cox model.Time-dependent Cox regression is an extension of the standard Cox proportional hazards model, introduced through the counting-process formulation developed by Therneau and Grambsch (2000), that allows one or more predictor variables to take different values at different points in a subject's follow-up period. It is the method of choice whenever a covariate — such as a laboratory measurement, a medication dose, or a disease severity score — changes over time rather than remaining fixed from study entry.
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ScholarGateBandingkan kaedah: Joint Model for Longitudinal and Survival Data · Time-Dependent Cox Regression. Dicapai 2026-06-18 daripada https://scholargate.app/ms/compare