Salīdzināt metodes

	IBD kartēšana	LD bloku analīze
Nozare	Ģenētika	Ģenētika
Saime	Process / pipeline	Process / pipeline
Izcelsmes gads	1987	2002
Autors	Eric Lander & David Botstein	Shaun Gabriel & Eric Lander
Tips	Genomic mapping method	Haplotype analysis method
Pirmavots	Lander, E. S., & Botstein, D. (1987). Homozygosity mapping of autosomal recessive disorders in consanguineous families. American Journal of Human Genetics, 36(3), 537–551.	Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B., & Lander, E. S. (2002). The structure of haplotype blocks in the human genome. Science, 296(5576), 2225–2229.
Citi nosaukumi	IBD mapping, Autozygosity mapping, Homozygosity mapping	Haplotype block analysis, LD mapping, Block structure analysis
Saistītās	4	5
Kopsavilkums	Identity-by-descent (IBD) mapping is a genetic mapping technique that identifies disease loci in consanguineous families or isolated populations by detecting homozygous chromosomal segments shared among affected individuals. Developed by Lander and Botstein in 1987, this method exploits the fact that rare disease alleles in related individuals must lie within shared ancestral DNA blocks. By mapping regions where affected individuals are homozygous at multiple markers, researchers can localize disease genes to narrowly defined genomic intervals without prior knowledge of the disease mechanism.	Linkage disequilibrium (LD) block analysis is a genomic method that partitions the human genome into distinct haplotype blocks—regions of limited recombination where variants are in strong statistical association. First systematically described by Gabriel and colleagues in 2002, this approach reveals the underlying structure of genetic variation and enables efficient genomic studies by reducing the number of variants needed to capture common diversity. LD block analysis forms the foundation of genome-wide association study (GWAS) design and modern population genetics.