방법 비교

	단일 세포 ChIP-seq 피크 호출	전장 후성유전체 연관 분석 (EWAS)
분야	생물정보학	생물정보학
계열	Process / pipeline	Process / pipeline
기원 연도	2019	2008–2011 (term and framework established c. 2011)
창시자	Grosselin et al.; Ku et al. (parallel independent development)	Rakyan, Down, Balding & Beck (conceptual framework); Illumina arrays enabled large-scale application
유형	Epigenomic profiling pipeline	Population-scale epigenomic association study
원전	Grosselin, K., Durand, A., Marsolier, J., Poitou, A., Marangoni, E., Nemati, F., ... & Vallot, C. (2019). High-throughput single-cell ChIP-seq identifies heterogeneity of chromatin states in breast cancer. Nature Genetics, 51(6), 1060-1066.	Rakyan, V. K., Down, T. A., Balding, D. J., & Beck, S. (2011). Epigenome-wide association studies for common human diseases. Nature Reviews Genetics, 12(8), 529–541.
별칭	scChIP-seq peak calling, single-cell chromatin profiling, scChIC-seq analysis, single-cell epigenomic peak detection	EWAS, methylome-wide association study, epigenetic association study, DNA methylation association study
관련	5	5
요약	Single-cell ChIP-seq peak calling is a bioinformatics pipeline that identifies genomic regions enriched for histone modifications or transcription factor binding in individual cells. By profiling chromatin states at single-cell resolution, it reveals epigenomic heterogeneity hidden in bulk ChIP-seq experiments, enabling researchers to map regulatory landscapes across distinct cell populations within a complex tissue sample.	An epigenome-wide association study (EWAS) is a hypothesis-free, genome-scale method that systematically tests whether epigenetic marks — predominantly CpG-site DNA methylation — differ between individuals with and without a trait, disease, or exposure. By scanning hundreds of thousands of genomic positions simultaneously, EWAS identifies loci where the epigenome is reproducibly associated with a phenotype, offering a layer of biological regulation that classical GWAS does not capture.