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단일 맹검 다중군 실험×단일 눈가림 무작위 대조 시험×
분야실험설계실험설계
계열Process / pipelineProcess / pipeline
기원 연도Mid-to-late 20th century1948 (formalized); single-blind variant established in mid-20th century clinical trial methodology
창시자Developed within the clinical trials tradition; formalized by Friedman, Furberg, and DeMets and others in the 20th centuryBradford Hill and colleagues (MRC streptomycin trial, 1948); blinding conventions codified in CONSORT guidelines
유형Controlled experimental designExperimental design — blinded randomized trial
원전Friedman, L. M., Furberg, C. D., & DeMets, D. L. (2010). Fundamentals of Clinical Trials (4th ed.). Springer. ISBN: 978-1441915849Schulz, K. F., Altman, D. G., Moher, D., & CONSORT Group. (2010). CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials. BMJ, 340, c332. DOI ↗
별칭single-masked multi-arm trial, single-blind multi-group experiment, unidirectional blinding multi-arm design, SB-MATsingle-masked RCT, single-blind RCT, single-blind trial, SB-RCT
관련55
요약A single-blind multi-arm experiment is a controlled experimental design that simultaneously compares three or more treatment conditions while blinding participants — but not investigators — to their group assignment. This configuration reduces response bias driven by participants' expectations, preserves operational feasibility when full blinding is impractical, and allows direct pairwise and omnibus comparisons across multiple arms within a single study.A single-blind randomized controlled trial (SB-RCT) is a rigorous experimental design in which participants are randomly assigned to treatment or control conditions while remaining unaware of which condition they have received. Investigators, outcome assessors, and data analysts are not blinded. By masking participants, the design eliminates placebo and nocebo response biases on the participant side, while preserving investigator flexibility to administer and monitor the intervention.
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