방법 비교

	다기관 중첩 환자-대조군 연구	중첩 환자-대조군 연구
분야	역학	역학
계열	Process / pipeline	Process / pipeline
기원 연도	1990s–2000s (multicenter adaptation)	1973–1977
창시자	Nested case-control: Norman Mantel (1973); multicenter extension widely adopted in EPIC and other large consortium studies (1990s–2000s)	Nathan Mantel (1973); D. C. Thomas (1977 formalization)
유형	Observational analytical study design	Hybrid observational study design
원전	Thomas, D.C. (1977). Addendum to: Methods of cohort analysis: appraisal by application to asbestos mining. Journal of the Royal Statistical Society, Series A, 140(4), 469–491.	Thomas, D. C. (1977). Addendum to: Methods of cohort analysis: Appraisal by application to asbestos mining. Journal of the Royal Statistical Society, Series A, 140(4), 469–491.
별칭	multicenter NCC, multi-site nested case-control, pooled nested case-control, nested case-control within multicenter cohort	NCC study, nested CC design, case-control within cohort, density sampling case-control
관련	6	6
요약	A multicenter nested case-control study embeds a case-control analysis within two or more geographically or institutionally distinct prospective cohorts. Cases who develop the outcome of interest are identified across all participating sites, then matched to controls sampled from the same risk sets, enabling pooled estimation of exposure-disease associations with greater statistical power and geographic generalizability than any single-center nested design.	A nested case-control study is an efficient observational design embedded within a defined cohort. For each participant who develops the outcome of interest (a case), a small number of matched controls are sampled from those still at risk at the same point in time. This density-sampling strategy yields odds ratios that approximate incidence-rate ratios from the full cohort at a fraction of the data-collection cost — making it the preferred alternative when measuring exposures for all cohort members would be prohibitively expensive or technically demanding.