방법 비교

	차단 무작위 대조 시험	교차 무작위 대조 시험 (crossover RCT)
분야	실험설계	실험설계
계열	Process / pipeline	Process / pipeline
기원 연도	1920s (Fisher's blocking principle); applied to RCTs from the 1940s onward	1960s (Grizzle 1965 for statistical foundations); widely used in clinical research since the 1970s
창시자	R. A. Fisher (blocking principle); systematic RCT application by Bradford Hill and later Pocock, Friedman et al.	Early formalized by statisticians including Bradford Hill and colleagues in clinical trials; theoretical framework developed by Grizzle (1965) and later Senn (2002)
유형	Experimental design	Experimental within-subject design
원전	Friedman, L. M., Furberg, C. D., DeMets, D. L., Reboussin, D. M., & Granger, C. B. (2010). Fundamentals of Clinical Trials (4th ed.). Springer. ISBN: 978-1441915856	Senn, S. (2002). Cross-over Trials in Clinical Research (2nd ed.). Wiley. ISBN: 978-0471496533
별칭	blocked RCT, block-randomized trial, stratified block randomization trial, permuted block randomization	crossover RCT, crossover trial, within-subject RCT, AB/BA crossover design
관련	5	5
요약	A blocked randomized controlled trial (blocked RCT) uses permuted-block randomization to ensure that treatment groups remain balanced in size — and optionally in key characteristics — throughout recruitment. Within each block of fixed or randomly varied size, all treatment allocations are present in equal numbers, so imbalance cannot accumulate even if the trial is stopped early. This makes blocked RCTs the standard randomization approach in clinical and behavioral intervention research.	A crossover randomized controlled trial (crossover RCT) is an experimental design in which each participant receives all study interventions in a randomized sequence, separated by a washout period. Because every participant serves as their own control, within-subject variability is eliminated from the treatment comparison, yielding greater statistical power per participant than a parallel-group RCT of equal size.