방법 비교

	실험 설계의 베이즈 최적화	반응 표면 분석법 (RSM)
분야	실험설계	실험설계
계열	Process / pipeline	Hypothesis test
기원 연도	1956 (foundational); formalized 1970s–1990s	1951
창시자	Lindley (1956); Chaloner & Verdinelli (1995) landmark review	George E. P. Box & K. B. Wilson
유형	Bayesian optimal experimental design	Second-order polynomial response surface model
원전	Chaloner, K., & Verdinelli, I. (1995). Bayesian Experimental Design: A Review. Statistical Science, 10(3), 273–304.	Box, G. E. P. & Wilson, K. B. (1951). On the experimental attainment of optimum conditions. Journal of the Royal Statistical Society, Series B, 13(1), 1–45.
별칭	Bayesian DOE, Bayesian optimal design, Bayesian experimental design, BDE	RSM, Central Composite Design, Box-Behnken Design, CCD
관련	3	7
요약	Bayesian design of experiments selects experimental runs by maximising a utility function — typically the expected information gain — computed over prior beliefs about model parameters. Unlike classical design, which optimizes algebraic criteria such as D-optimality under fixed assumptions, Bayesian DOE incorporates prior knowledge and uncertainty about the system, yielding designs that are optimal in expectation across all plausible parameter values.	Response Surface Methodology is a collection of statistical and mathematical techniques for building an empirical second-order polynomial model that relates a continuous response variable to two or more controllable input factors, and then locating the factor settings that optimize that response. The approach was introduced by George E. P. Box and K. B. Wilson in their landmark 1951 paper and has since become a cornerstone of process optimization across engineering, chemistry, food science, and pharmaceutics.