방법 비교

	적응형 무작위 배정 임상시험	Randomized Controlled Trial (RCT)
분야	실험설계	실험설계
계열	Process / pipeline	Hypothesis test
기원 연도	1980s–2000s (formalized; earlier sequential testing roots from Wald, 1947)	1948
창시자	Donald Berry and others; foundational adaptive trial methods developed through 1980s–2000s biostatistics literature	James Lind (early precursor, 1747); modern formulation: Austin Bradford Hill & Medical Research Council (1948)
유형	Experimental design — adaptive variant of RCT	Interventional comparative study
원전	Chow, S.-C., & Chang, M. (2008). Adaptive Design Methods in Clinical Trials. Chapman & Hall/CRC. ISBN: 978-1584887690	Schulz, K.F., Altman, D.G., Moher, D., for the CONSORT Group (2010). CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials. BMJ, 340, c332.
별칭	Adaptive RCT, Response-adaptive RCT, Adaptive clinical trial, Platform trial	RCT, randomised controlled trial, clinical trial, Randomize Kontrollü Çalışma (RCT) Tasarımı
관련	6	7
요약	An adaptive randomized controlled trial (adaptive RCT) is an experimental design in which pre-specified rules allow modifications to the trial while it is ongoing — such as changing allocation ratios, dropping underperforming arms, or stopping early for efficacy or futility — based on accumulating interim data. These adaptations are planned before the trial starts and governed by statistical rules to preserve Type I error control and validity.	A randomized controlled trial (RCT) is the gold standard experimental design in clinical and health research, in which participants are randomly allocated to a treatment group or a control group so that the effect of an intervention can be measured with the highest possible degree of internal validity. The modern parallel-group RCT was formalized by Austin Bradford Hill and the Medical Research Council in their landmark streptomycin trial of 1948, and its reporting is governed today by the CONSORT 2010 guidelines (Schulz et al., 2010).