방법 비교

	적응형 대조군 실험 설계	적응형 무작위 배정 임상시험
분야	실험설계	실험설계
계열	Process / pipeline	Process / pipeline
기원 연도	1994 (formal adaptive framework); wider adoption 2000s–2010s	1980s–2000s (formalized; earlier sequential testing roots from Wald, 1947)
창시자	Peter Bauer and Klaus Kohne (adaptive interim analysis framework, 1994); broader adaptive design methodology developed by Scott Chow and Mark Chang	Donald Berry and others; foundational adaptive trial methods developed through 1980s–2000s biostatistics literature
유형	Adaptive experimental design	Experimental design — adaptive variant of RCT
원전	Chow, S.-C., & Chang, M. (2008). Adaptive Design Methods in Clinical Trials. Chapman and Hall/CRC. ISBN: 978-1584886760	Chow, S.-C., & Chang, M. (2008). Adaptive Design Methods in Clinical Trials. Chapman & Hall/CRC. ISBN: 978-1584887690
별칭	adaptive controlled experiment, adaptive two-arm controlled design, adaptive parallel-group design, flexible controlled trial design	Adaptive RCT, Response-adaptive RCT, Adaptive clinical trial, Platform trial
관련	4	6
요약	An adaptive control group experimental design is an experiment that assigns participants to at least one treatment arm and one concurrent control group, while allowing pre-specified modifications to the trial — such as sample size re-estimation, early stopping, or allocation ratio changes — based on accumulating data. Adaptations are governed by decision rules established before the study begins, preserving Type I error control while improving efficiency.	An adaptive randomized controlled trial (adaptive RCT) is an experimental design in which pre-specified rules allow modifications to the trial while it is ongoing — such as changing allocation ratios, dropping underperforming arms, or stopping early for efficacy or futility — based on accumulating interim data. These adaptations are planned before the trial starts and governed by statistical rules to preserve Type I error control and validity.