手法を比較

	唾液バイオマーカー分析	歯列浸食指数
分野	歯学	歯学
系統	Process / pipeline	Process / pipeline
提唱年	2000s+ (clinical application)	1990s+ (systematic indices)
提唱者	Multiple innovators (Giannobile, Malamud, et al.)	Multiple indices (Lussi index, BEWE, etc.)
種類	Laboratory and point-of-care diagnostics	Clinical assessment index
原典	Giannobile, W. V., McDevitt, J. T., Niedbala, R. S., Malamud, D., & Prozorovsky, T. (2009). Translating molecular diagnostics into clinical practice: Designing the next generation of oral health technologies. Advances in Dental Research, 23(1), 80-89.	Lussi, A., Jaeggi, T., & Zero, D. (2004). The role of diet in the aetiology of dental erosion. Caries Research, 38(1), 34-44.
別名	saliva testing, salivary diagnostics, oral biomarker assessment	tooth wear index, erosion severity index, TSL index
関連	3	3
概要	Salivary biomarker analysis detects protein, molecular, or microbial markers in saliva that indicate oral and systemic disease. Salivary diagnostics assess risk and activity of dental caries, periodontal disease, oral cancer, and other conditions. Biomarkers include antimicrobial proteins (lysozyme, lactoferrin), inflammatory mediators (interleukins, TNF-alpha), cariogenic bacteria (Streptococcus mutans), and virulence factors. Point-of-care saliva testing offers rapid, non-invasive alternatives to conventional laboratory methods, enabling chairside diagnosis and personalized risk assessment.	The Dental Erosion Index is a systematic clinical assessment tool that quantifies the severity of tooth surface loss caused by non-carious erosive agents (acidic substances, mechanical abrasion, or biological factors). Multiple index systems exist (e.g., Lussi Index, Basic Erosive Wear Examination or BEWE), each scoring erosion based on the extent and depth of surface loss on coronal and cervical tooth surfaces. Erosion assessment is critical for identifying patients at risk for advanced tooth loss, determining preventive interventions, and guiding restorative management.