手法を比較

	リスク調整済み用量反応分析	Cox Proportional Hazards
分野	疫学	疫学
系統	Process / pipeline	Process / pipeline
提唱年	1980s-1990s (formalized in modern epidemiology)	1972
提唱者	Sander Greenland; Kenneth Rothman (foundational epidemiological methods)	Sir David Roxbee Cox
種類	Epidemiological modeling technique	Semi-parametric regression model
原典	Greenland, S. (1995). Dose-response and trend analysis in epidemiology: alternatives to categorical analysis. Epidemiology, 6(4), 356-365.	Cox, D. R. (1972). Regression models and life-tables. Journal of the Royal Statistical Society: Series B (Methodological), 34(2), 187–202.
別名	confounder-adjusted dose-response, covariate-adjusted dose-response modeling, risk-stratified dose-response analysis, adjusted exposure-response analysis	Cox regression, Cox PH model, proportional hazards model, CPH
関連	4	5
概要	Risk-adjusted dose-response analysis quantifies the relationship between increasing levels of an exposure (dose) and the probability or magnitude of an outcome (response), while simultaneously controlling for baseline risk factors that could confound or modify this relationship. The method is widely applied in clinical epidemiology, pharmacoepidemiology, and environmental health research to isolate the causal contribution of exposure intensity from background risk heterogeneity among participants.	The Cox proportional hazards model is a semi-parametric regression method that estimates the effect of one or more covariates on the hazard — the instantaneous rate of an event such as death, relapse, or failure — while making no assumption about the shape of the baseline hazard function. Introduced by David Cox in 1972, it is the dominant tool for multivariable survival analysis in clinical and epidemiological research.