手法を比較

	前向き用量反応分析	Cox Proportional Hazards
分野	疫学	疫学
系統	Process / pipeline	Process / pipeline
提唱年	1965 (Hill's criteria); widely applied through 1980s–present	1972
提唱者	Bradford Hill (causal criteria including dose-response, 1965); formalized in modern epidemiology by Rothman, Greenland and others	Sir David Roxbee Cox
種類	Analytical epidemiological study design	Semi-parametric regression model
原典	Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641	Cox, D. R. (1972). Regression models and life-tables. Journal of the Royal Statistical Society: Series B (Methodological), 34(2), 187–202.
別名	prospective exposure-response analysis, prospective trend analysis, forward-looking dose-response study, prospective gradient analysis	Cox regression, Cox PH model, proportional hazards model, CPH
関連	4	5
概要	Prospective dose-response analysis is an epidemiological approach that measures exposure levels in a defined population before outcomes occur, then quantifies how the risk or magnitude of an outcome changes systematically as exposure increases. By collecting exposure data prospectively, researchers can establish temporal sequence, reduce recall bias, and assess whether a biological gradient — one of Hill's classic causal criteria — exists between the agent of interest and a health outcome.	The Cox proportional hazards model is a semi-parametric regression method that estimates the effect of one or more covariates on the hazard — the instantaneous rate of an event such as death, relapse, or failure — while making no assumption about the shape of the baseline hazard function. Introduced by David Cox in 1972, it is the dominant tool for multivariable survival analysis in clinical and epidemiological research.