手法を比較

	メンデルランダム化	回帰不連続デザイン（Regression Discontinuity Design, RDD）
分野	因果推論	因果推論
系統	Regression model	Regression model
提唱年	1997	2008
提唱者	George Davey Smith	Imbens & Lemieux (guide to practice); Cattaneo, Idrobo & Titiunik (practical introduction)
種類	Genetic instrumental variable framework	Quasi-experimental causal design
原典	Davey Smith, G., & Hemani, G. (2014). Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Human Molecular Genetics, 23(R1), R89-R98.	Imbens, G. W., & Lemieux, T. (2008). Regression Discontinuity Designs: A Guide to Practice. Journal of Econometrics, 142(2), 615-635.
別名	MR	RDD, regression discontinuity design, sharp RDD, fuzzy RDD
関連	2	5
概要	Mendelian randomization is a method for estimating causal effects of exposures on outcomes using genetic variants as instrumental variables. Introduced by George Davey Smith in the 1990s, it exploits Mendel's law of segregation to remove confounding bias. It has become a cornerstone technique in epidemiological causal inference.	Regression Discontinuity Design is a quasi-experimental method that identifies a causal effect by locally comparing units just above and just below a cutoff on a continuous assignment (running) variable. Formalised for applied work by Imbens and Lemieux (2008) and developed as a practical framework by Cattaneo, Idrobo, and Titiunik (2020), it estimates a local average treatment effect (LATE) at the threshold.