手法を比較
選択した手法を並べて確認できます。異なる行はハイライト表示されます。
| 相同性モデリング（Homology Modeling）× | PPIネットワークトポロジー× | |
|---|---|---|
| 分野 | バイオインフォマティクス | バイオインフォマティクス |
| 系統 | Process / pipeline | Process / pipeline |
| 提唱年≠ | 1993 | 2000 |
| 提唱者≠ | Andrej Sali | Peter Uetz |
| 種類≠ | Comparative structure prediction pipeline | Network analysis pipeline |
| 原典≠ | Sali, A. & Blundell, T. L. (1993). Comparative protein modelling by satisfaction of spatial restraints. Journal of Molecular Biology, 234(3), 779-815. DOI ↗ | Uetz, P., Giot, L., Cagney, G., Mansfield, T. A., Judson, R. S., Knight, J. R., ... & Lomax, J. (2000). A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature, 403(6770), 623-627. DOI ↗ |
| 別名≠ | comparative modeling, template-based modeling | protein interaction networks, interactome analysis, network topology |
| 関連≠ | 4 | 3 |
| 概要≠ | Homology modeling, also called comparative modeling, predicts the three-dimensional structure of a protein using an experimentally-solved structure of a homologous protein as a template. Introduced by Sali and Blundell in 1993, this method exploits the principle that homologous proteins share similar spatial structures despite differing in amino acid sequence. | Protein-protein interaction network analysis identifies and characterizes the structural properties of cellular interaction networks. Pioneered by Uetz and colleagues through large-scale yeast two-hybrid screening, this approach reveals topological features like hubs, modules, and motifs that encode functional organization and disease associations. |
| ScholarGateデータセット ↗ |
|
|